化学结构 1963年Brockmann将四氢丁省醌-5,12的各种抗菌素归纳成一大类,并命名为蒽环类抗菌素。蒽环类抗菌素是糖甙类,配基是上述醌的衍生物联结一个或多个相同的或不同的糖。在配基的特定位置上有不同的取代基,如羟基、甲氧基、甲酯基、乙酰基、α-羟基乙酰基、乙基或甲基。羟基通常在1、2、4、6、7、9、10和11位上,甲氧基在2、4位上,甲酯基在10位上,而在9位上是乙酰基、羟基 Chemical Structure In 1963, Brockmann summarized the various antibiotics of tetrahydrin-quinone-5,12 into a broad category and named anthracycline antibiotics. Anthracyclines are glycosides, ligands of which quinone derivatives are linked to one or more of the same or different sugars. There are different substituents at specific positions on the ligand, such as hydroxy, methoxy, methyl ester, acetyl, alpha-hydroxyacetyl, ethyl or methyl. The hydroxyl group is usually at positions 1, 2, 4, 6, 7, 9, 10 and 11, the methoxy group is at the 2,4 position, the carbomethoxy group is at the 10 position and the 9 position is acetyl group,