Ⅱ型单纯疱疹病毒(HSV-2)是一种主要引起人类生殖器疱疹的病原体,在世界范围内广泛流行,不发达国家和地区尤为严重。HSV-2感染不仅严重威胁人类健康,同时也造成大量的经济损失。对HSV-2疫苗的研究已开展多年,历经了灭活疫苗、减毒活疫苗、重组亚单位疫苗、肽疫苗、DNA疫苗等多个阶段,并取得了一定进展,然而到目前为止,全球仍无一种HSV-2疫苗被批准上市。本文对近年来HSV-2疫苗的研究进展作一综述。 Herpes simplex virus type 2 (HSV-2) is a major causative agent of human genital herpes, which is endemic in the world, especially in underdeveloped countries and regions. HSV-2 infection not only poses a serious threat to human health, but also causes substantial economic losses. The research on HSV-2 vaccine has been carried out for many years and has gone through several stages, such as inactivated vaccine, live attenuated vaccine, recombinant subunit vaccine, peptide vaccine and DNA vaccine, and some progress has been made. However, up to now, None of the HSV-2 vaccines have been approved for marketing. This review summarizes the progress of HSV-2 vaccine in recent years.