近年来人们对C肽的活性有了进一步认识。C肽可改善糖尿病微血管病变和神经病变 ,其作用机制与升高组织Na+ K+ ATP酶活性及激活内皮型一氧化氮合酶促进一氧化氮合成有关。细胞膜上C肽受体的发现 ,为研究C肽的生物活性提供分子生物学基础。C肽与胰岛素联合治疗已显示其临床应用前景 ,但仍需进一步研究 In recent years, people have further understanding of the activity of C-peptide. C peptide can improve diabetic microangiopathy and neuropathy, the mechanism of which is related to the increase of tissue Na + K + ATPase activity and activation of endothelial nitric oxide synthase to promote the synthesis of nitric oxide. The discovery of C-peptide receptor on cell membrane provides the molecular biology basis for studying the biological activity of C-peptide. C peptide and insulin combination therapy has shown its clinical application prospects, but still need further study