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2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine is the key intermediate of Silodosin,theα_1-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia.In order to obtain this intermediate,we developed a novel synthetic route by utilizing 2- nitrochlorobenzene as the starting material via O-alkylation,reduction,diazotization,acidolysis,etherification,condensation and hydrazinolysis.The highlight of this method lies on its convenience and economy in accessing this intermediate.
2- [2- (2,2,2-Trifluoroethoxy) phenoxy] ethanamine is the key intermediate of Silodosin, the α_1-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia. In order to obtain this intermediate, we developed a novel synthetic route by utilizing 2-nitrochlorobenzene as the starting material via O-alkylation, reduction, diazotization, acidolysis, etherification, condensation and hydrazinolysis. The highlight of this method lies on its convenience and economy in accessing this intermediate.