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目的:探讨谷胱甘肽S转移酶P1(GSTP1)和四羟基壬烯(4-HNE)在前列腺癌组织中的表达及其临床意义。方法:采用免疫组化方法检测40例前列腺癌组织及42例BPH组织中GSTP1和4-HNE的表达,分析GSTP1和4-HNE的表达与Gleason分级之间的关系。结果:GSTP1在BPH组织中为高表达(92.9%),40例前列腺癌组织中GSTP1表达率在高、中、低分化癌中分别为58.3%、20.0%、16.7%,呈下降趋势,两组GSTP1表达差异有统计学意义(P<0.01)。4-HNE在前列腺增生组织中阳性表达率较低,仅为5.0%。40例前列腺癌组织中4-HNE高表达,在高、中、低分化癌中分别为91.6%、100.0%、100.0%,呈明显上升趋势,两组4-HNE表达差异有统计学意义(P<0.01)。前列腺癌组织中GSTP1和4-HNE阳性表达呈负相关(r=-2.73,P<0.01)。结论:GSTP1表达缺失和4-HNE的高表达,可能在前列腺癌的进展中起重要作用。
Objective: To investigate the expression and clinical significance of glutathione S-transferase P1 (GSTP1) and tetrahydroxynonene (4-HNE) in prostate cancer. Methods: The expressions of GSTP1 and 4-HNE in 40 cases of prostate cancer and 42 cases of BPH tissues were detected by immunohistochemistry. The relationship between GSTP1 and 4-HNE expression and Gleason grade was analyzed. Results: GSTP1 was highly expressed in BPH tissues (92.9%). The expression rates of GSTP1 in 40 cases of prostate cancer tissues were 58.3%, 20.0% and 16.7%, respectively, showing a decreasing trend. Two groups The difference of GSTP1 expression was statistically significant (P <0.01). The positive rate of 4-HNE in benign prostatic hyperplasia was lower, only 5.0%. The 4-HNE overexpression in 40 cases of prostate cancer was 91.6%, 100.0% and 100.0% respectively in high, moderate and poorly differentiated cancers, showing a significant upward trend, with a significant difference in 4-HNE expression between the two groups (P <0.01). The positive expression of GSTP1 and 4-HNE in prostate cancer tissues was negatively correlated (r = -2.73, P <0.01). Conclusion: Loss of GSTP1 expression and high expression of 4-HNE may play an important role in the progression of prostate cancer.