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目的探讨中性粒细胞/淋巴细胞比率(NLR)与急性缺血性脑血管病的相关性。方法比较急性脑梗死(ACI)患者(ACI组,121例)、短暂性脑缺血发作(TIA)患者(TIA组,62例)和健康体检者(对照组,65例)NLR水平,分析NLR水平与ACI和TIA的相关性。发病后1个月随访,依据GOS将ACI组分为预后良好组(GOS评分4~5分)和预后不良组(GOS评分1~3分),比较两组患者NLR水平,分析NLR水平与ACI预后的相关性。结果 ACI组和TIA组NLR水平均高于对照组,且ACI组高于TIA组(P<0.05);ACI预后不良组NLR水平高于预后良好组(P<0.05);ACI组NLR水平与GOS评分呈负相关(r_s=-0.489,P<0.01)。结论 NLR水平与急性缺血性脑血管病的临床分类及ACI预后密切相关,可用于ACI和TIA的鉴别诊断和ACI患者近期预后的评估。
Objective To investigate the correlation between neutrophil / lymphocyte ratio (NLR) and acute ischemic cerebrovascular disease. Methods NLR levels in 121 patients with acute cerebral infarction (ACI), 121 with transient ischemic attack (TIA) and 62 healthy controls (control group, 65 patients) were compared. The levels of NLR Correlation of levels with ACI and TIA. After one month follow-up, the ACI patients were divided into two groups according to GOS: good prognosis group (GOS score 4 to 5) and poor prognosis group (GOS score 1 to 3). The NLR levels were compared between the two groups. Correlation of prognosis. Results The NLR levels in ACI group and TIA group were higher than those in control group, and the ACI group was higher than TIA group (P <0.05). The NLR level in ACI group with poor prognosis was higher than that in good prognosis group (P <0.05) The score was negatively correlated (r_s = -0.489, P <0.01). Conclusion The level of NLR is closely related to the clinical classification of acute ischemic cerebrovascular disease and the prognosis of ACI. It can be used in the differential diagnosis of ACI and TIA and the assessment of the short-term prognosis of patients with ACI.