设计合成了１１个新的异苯并呋喃酮３乙酰胺类化合物，它们均未见文献报道，产物经核磁共振氢谱和元素分析确证．抗惊实验表明：当酰胺氮原子上的取代基为脂肪取代基且碳原子总数在６～１０个之间时，该类化合物才有较好的抗惊活性．并对其构效关系进行了初步讨论 11 new isobenzofuranone  3 acetamides were designed and synthesized. None of them were reported in the literature. The products were confirmed by 1H NMR and elemental analysis. Anti-shock experiments show that: when the amide nitrogen atom substituents for the aliphatic substituents and the total number of carbon atoms between 6 to 10, these compounds have better anti-shock activity. And the structure-activity relationship of the initial discussion