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目的探讨剖宫产与支气管哮喘(哮喘)发生的关系。方法检索Pubmed、中国知网、万方数据库和重庆维普数据库中剖宫产与哮喘发生的相关文献,并应用RevMan 5.0软件对符合入选标准的文献进行异质性检验和效应值合并,同时进行敏感性分析和偏倚评估。结果纳入符合条件的相关文献共8篇,其中哮喘组32 622例,对照组890 876例。剖宫产与哮喘发生关系的研究间有异质性(P=0.000 4),故采用随机效应模型进行分析。剖宫产与哮喘的各研究的合并OR值(95%CI)为1.22(1.10～1.36),Z=3.76,P=0.000 2。各研究的敏感性分析结果稳定且无发表偏倚。结论剖宫产与哮喘的发生密切相关。
Objective To investigate the relationship between cesarean section and bronchial asthma (asthma). Methods PubMed, CNKI, Wanfang database and Chongqing VIP database were searched for articles related to cesarean section and asthma. RevMan 5.0 software was used to carry out heterogeneity test and effect value merging of the documents meeting the inclusion criteria, Sex analysis and bias assessment. Results A total of 8 eligible articles were included, 32 622 in the asthma group and 8 876 in the control group. There was a heterogeneity between cesarean section and asthma (P = 0.000 4), so random effects model was used to analyze. The combined odds ratio (95% CI) for each study of cesarean section and asthma was 1.22 (1.10-1.36), Z = 3.76, P = 0.0002. Sensitivity analysis results for each study were stable and unpublished. Conclusion Cesarean section is closely related to the occurrence of asthma.