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目的:探讨SLC25A12基因多态性与儿童孤独症的关联性。方法:用PCR-单链构象多态性(S ingle StrandedConform ational Polymorph ism)法检测105例日本孤独症患儿及其父母的SLC25A12基因多态性,用传递不平衡检验(Transm issionD isequ ilibrium Test)进行统计学分析。结果:2个SNPs(rs3765166、rs3770448)均无连锁不平衡(P≥0.317)。结论:SLC25A12基因多态性与日本孤独症无关联,孤独症的病因基因有待于进一步研究。
Objective: To investigate the association between SLC25A12 gene polymorphism and autism in children. Methods: SLC25A12 gene polymorphism was detected in 105 children with autism in Japan and their parents by S-Stranded Conflation ational Polymorphism. Transm ission D isequilibrium Test Statistical analysis. Results: Two SNPs (rs3765166, rs3770448) had no linkage disequilibrium (P≥0.317). Conclusion: SLC25A12 gene polymorphism is not associated with autism in Japan, and the etiological genes of autism need further study.