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实验观察了四氧嘧啶诱发糖尿病大鼠连续饲养１１０ｄ后体内肾素－血管紧张素系统的变化。结果表明，血浆和心脏的血管紧张素 Ⅱ（ ａｎｇｉｏｔｅｎｓｉｎ Ⅱ， Ａｎｇ Ⅱ）含量无明显变化，而肾脏的ＡｎｇⅡ含量却明显低于正常对照组（０．引±０．０２； ０．４６±０．０２ｎｇ／ｇ湿重；Ｐ＜０．０５）。另外，心脏的心钠素（ＡＮＰ）含量在糖尿病大鼠与正常对照组之间无差别，血中的糖化血红蛋白含量基本无变化。上述结果表明，糖尿病大鼠早期心脏可能无明显损伤，而肾脏的肾素一血管紧张素系统活性降低。
The changes of renin-angiotensin system in vivo after 110 days of continuous feeding in alloxan-induced diabetic rats were observed. The results showed that plasma and cardiac angiotensin Ⅱ (Ang Ⅱ) content had no significant change, while the kidney Ang Ⅱ content was significantly lower than the normal control group (0. ± 0.02; 02 ng / g wet weight; P <0.05). In addition, the content of atrial natriuretic peptide (ANP) in diabetic rats and normal control group no difference between the blood glycated hemoglobin content remained unchanged. The above results indicate that there may be no obvious damage to the early heart of diabetic rats and the renin-angiotensin system activity of the kidney is reduced.