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目的 了解溴氰菊酯的毒性、刺激性、蓄积毒性、致敏性和致突变性。方法 按标准方法分别作大小鼠急性经口毒性 ;大鼠经皮、吸入毒性 ;皮肤、眼刺激性 ;大鼠蓄积毒性和亚慢性经口毒性试验 ;豚鼠致敏试验 ;致突变试验包括Ames、小鼠骨髓微核和睾丸精母细胞染色体畸变试验。结果 大小鼠急性LD50 分别为 2 78mg/kg和 5 6 2mg/kg ;大鼠经皮LD50 >2 0 0 0mg/kg ;急性吸入LC50 >3 0 0 0mg/m3 ;无皮肤刺激性 ,轻度眼刺激性 ;蓄积系数 2 3 ;致敏率为 0 ;Ames试验结果阴性 ;微核和染色体在高剂量组 ( 11 2 4mg/kg)与阴性对照组相比有高度显著性差异 (P <0 0 1) ;大鼠 90天亚慢性经口的最大无作用剂量为 2 82 5mg/kg。结论 溴氰菊酯有明显的蓄积作用 ,为弱致敏物 ,一定剂量下可引起骨髓微核和睾丸精母细胞染色体畸变率增加 ,提示它是一种可能致突变物
Objective To understand the toxicity, irritation, accumulative toxicity, allergenicity and mutagenicity of deltamethrin. Methods Acute oral toxicity was induced in rats and rats according to standard methods. Rat percutaneous and inhaled toxicity. Skin and eye irritation. Rat accumulative toxicity and subchronic oral toxicity test. Guinea pig sensitization test. Mutagenicity tests included Ames, Chromosome aberration test in mouse bone marrow micronucleus and testicular spermatocyte. Results The acute and chronic LD50 of rat and rat were 788mg / kg and 562mg / kg, respectively. The LD50> 200mg / kg of rat percutaneous LD50> 300mg / m3 of acute inhalation. Irritation; accumulation coefficient of 23; sensitization rate of 0; negative Ames test results; micronuclei and chromosomes in the high-dose group (11 2 4mg / kg) compared with the negative control group was highly significant difference (P <0 0 1). The maximal non-action dose of sub-chronic oral administration in rats for 90 days was 2 82 5 mg / kg. Conclusion Deltamethrin has a significant accumulation effect and is a weak allergen. Under a certain dose, the chromosome aberration rate of micronuclei and testicular spermatocytes in bone marrow can be increased, suggesting that it is a possible mutagen