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细胞膜Ca~(2+)转运功能异常在自发性高血压大鼠(SHR)发病过程中有重要作用。川芎嗪作为临床上广泛使用的活血化瘀药,其扩血管效应是否通过影响细胞膜Ca~(2+)转运机制,目前所知甚少。本文观察了川芎嗪对SHR和WKY大鼠红细胞膜外翻囊泡(IOV)Ca~(2+)摄取的影响,拟探讨在正常血压和高血压状态下其作用的差异和意义。
Abnormality of Ca2 + transport in cell membrane plays an important role in the pathogenesis of spontaneously hypertensive rats (SHR). As a clinically widely used traditional Chinese medicine for promoting blood circulation and removing blood stasis, ligustrazine has little or no notable understanding whether its vasodilator effect affects Ca 2+ transport mechanism of the cell membrane. In this paper, the effects of ligustrazine on the uptake of Ca ~ (2 +) in the erythrocyte valgus (IOV) of SHR and WKY rats were observed, and the differences and significance of its application in normal blood pressure and hypertension were investigated.