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在盐酸底液中，单硝酸异山梨酯（简称ＩＳＭＮ）在汞电极上于－ ０．５０Ｖ和－０．８８Ｖ（ｖｓ．ＳＣＥ）可产生两个不可逆的还原峰。用循环伏安法（ＣＶ），微分脉冲极谱（ＤＰＰ），常规脉冲极谱（ＮＰＰ）及恒电位电解等多种电化学方法研究了该本系的电化学行为和电极机理，两个峰的产生是因硝酸酯的两步不可逆还原所致。利用第一个峰单扫描极谱法测定了片剂中单硝酸异山梨酯的含量，线性范围为０．０２～２０ｍ ｇ／Ｌ，检测下限为０．０１ｍｇ／Ｌ，并探讨了影响灵敏度的主要因素。
Isosorbide mononitrate (referred to as ISMN) produced two irreversible reduction peaks at-0.50V and -0.88V (vs.SCE) on the mercury electrode in the HCl solution. The electrochemical behavior and electrode mechanism of this series were studied by cyclic voltammetry (CV), differential pulse polarography (DPP), conventional pulse polarography (NPP) and potentiostatic electrolysis. The two peaks The production is due to two-step irreversible nitrate reduction. The first peak single-sweep polarographic method was used to determine the isosorbide mononitrate content in the tablets, with a linear range of 0.02 ~ 20 m g / L and a detection limit of 0.01 mg / L. The effects of sensitivity major factor.