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心衰恶化时,肾上腺素神经系统的活动亦逐渐增强,因而,认为长期肾上腺素能神经的兴奋参与心衰的病理过程。作者应用放射免疫方法测定心脏移植严重心衰患者的心室肌α、β受体,并取自愿者的心脏作为对照,研究了心衰时心室肌肾上腺α、β受体密度和亲合力的变化。结果表明:在衰竭心脏,心室肌β受体密度明显减少,但亲合力并无改变。在正常心脏,β_1受体约占受体总数的80%,心衰时为60%。衰竭心脏的β_2受体绝对数量虽无改变,但由于β_1受体减少,使β_2受体所占百分比高于正常心脏。人心室肌α_1受体的密度明显低于β_1受体,其比
When heart failure worsens, the activity of the adrenaline nervous system gradually increases. Therefore, it is considered that the excitement of long-term adrenergic nerves is involved in the pathological process of heart failure. The authors used radioimmunoassay to determine the a and b receptors of ventricular myocardium in patients with severe heart failure. The heart of volunteers was used as a control to study the changes of alpha and beta receptor density and avidity in ventricular myocardium during heart failure. The results showed that in the failing heart, the density of β receptor in myocardium decreased significantly, but the affinity did not change. In normal hearts, the beta 1 receptor accounts for about 80% of the total number of receptors and 60% of heart failure. Although there is no change in the absolute number of β_2 receptors in failing heart, the percentage of β_2 receptors is higher than normal heart due to the decrease of β_1 receptors. The density of α_1 receptor in human ventricular myocytes was significantly lower than that of β_1 receptors