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目的探讨C反应蛋白(CRP)与降钙素原(PCT)对重症颅脑损伤患者继发肺部感染的诊断价值。方法选取2016年1至2017年2月在我院治疗的重型颅脑损伤患者98例,根据临床结局分为感染组(41例)和非感染组(57例),比较2组患者在治疗期间血清CRT、PCT水平变化,分析2项指标单独检测和联合检测对诊断颅脑外伤继发肺部感染的敏感度和特异度。结果患者入院第3d、5d、7d感染组患者的血清CRP、PCT水平均明显高于非感染组(P<0.05),CRP+PCT联合检测的灵敏性为93.23%,特异性为86.32%,明显高于单独检测CRP、PCT的灵敏性及特异性。结论 CRT、PCT是诊断重型颅脑损伤患者肺部感染的敏感指标,联合检测的敏感度和特异度更佳,对于疾病的早期诊断具有较高价值。
Objective To investigate the diagnostic value of C-reactive protein (CRP) and procalcitonin (PCT) in the diagnosis of secondary pulmonary infection in patients with severe craniocerebral injury. Methods A total of 98 patients with severe craniocerebral injury who were treated in our hospital from January 2016 to February 2017 were divided into infection group (n = 41) and non-infection group (n = 57) according to the clinical outcome. The patients in two groups were compared Serum levels of CRT and PCT were analyzed. The sensitivity and specificity of two independent tests and combined tests on the diagnosis of secondary lung infections after craniocerebral trauma were analyzed. Results The serum levels of CRP and PCT in the patients on the 3rd, 5th and 7th day after admission were significantly higher than those in the non-infected group (P <0.05). The sensitivity and specificity of the combined detection of CRP and PCT were 93.23% and 86.32%, respectively Higher than CRP alone, PCT sensitivity and specificity. Conclusions CRT and PCT are sensitive indicators for the diagnosis of pulmonary infection in patients with severe craniocerebral injury. The combined detection is more sensitive and specific, which is of great value in the early diagnosis of the disease.