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硅性肾病是一种罕见疾病。主要见于煤矿及铁矿工人。本文报告牙科技师中的第一个病例。男性,55岁,作假牙已25年,擅长用陶瓷制作假牙。五年前出现下肢浮肿,蛋白尿:4g/24h,尿沉渣无异常,肾功正常。四年前出现用力后呼吸困难,胸片示肺气肿、腋区有网状及结节状改变,逐收住入院。化验结果:血尿素30mmol/L,肌酐540umol/L,钾7.4mmol/L,血浆碳酸氢盐15mmol/L,血红蛋白7.9g/dl。放免检查:类风湿因子、冷球蛋白、抗核抗体、抗ADN抗体及抗基底膜抗体均为明显。溶血补体检查正常。循环免疫复合物阳性。肾超声检查正常。组织学检查示三分之二肾小球完全硬化性玻璃样变。其余肾小球有散在性毛细
Silicone nephropathy is a rare disease. Mainly seen in coal mines and iron ore workers. This article reports the first case of a dental technician. Male, 55 years old, has 25 years as a denture, good at making dentures with ceramic. Lower extremity edema five years ago, proteinuria: 4g / 24h, urinary sediment was normal, normal renal function. Four years ago appeared hard after breathing difficulties, chest X-ray showed emphysema, axillary mesh and nodular changes, admitted by admission. Laboratory results: blood urea 30mmol / L, creatinine 540umol / L, potassium 7.4mmol / L, plasma bicarbonate 15mmol / L, hemoglobin 7.9g / dl. RIA: rheumatoid factor, cold globulin, antinuclear antibodies, anti-ADN antibodies and anti-basal membrane antibodies are obvious. Hemolytic complement check normal. Cyclic immune complex positive. Renal ultrasound was normal. Histological examination showed two-thirds of glomeruli completely hardenable hyalinized. The remaining glomeruli have scattered capillaries