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目的：分析河南省三市(周口、许昌、平顶山)2010-2012年狂犬病流行病学特征。方法收集2010-2012年狂犬病疫情资料，应用描述流行病学方法对资料进行回顾性分析。结果周口、许昌、平顶山2010-2012年有2/3县市报道狂犬病病例，共报告42例狂犬病病例，年度发病率和地区发病率之间无统计学差异；夏季发病较多，有9月与2月两个发病高峰；男性多于女性，45-59岁组报告最多，农民占绝大多数达76.2%；75.0%的病例于9d内死亡，有病例逃逸现象。结论周口、许昌、平顶山三市狂犬病流行形势严峻，需加强群防群控。“,”Objective To analyze the epidemiological characteristics of rabies from 2010 to 2012 in three cities(Zhoukou, Xuchang, Pingdingshan) in Henan Province. Method The data of rabies from 2010 to 2012 was collected and carried out retrospective analysis by epidemiologic methods. Results Total of 42 human rabies cases were reported in 2/3 counties in three cities from 2010 to 2012, the trend of rabies prevalence in each cities were different from each other, most of the cases happened in summer, it had 2 outbreak high peaks(February and September) in a year. More male than female, age 45-59 was reported most, 76.2% injuries were farmers and 75.0% injuries were died in 9 days, some patients were escaped. Conclusions The rabies epidemic situation of cities of Zhoukou, Xuchang, Pingdingshan were very serious, need to strengthen cluster controlling.