无环鸟苷(acyclovir,ACV)是一种新合成的抗病毒药,又名无环鸟嘌呤核苷、开链鸟嘌呤核苷,化学名9[(2-羟乙氧基)甲基]鸟嘌呤,系第9位上带无环侧链的鸟嘌呤衍化物,结构上极似2-脱氧鸟嘌呤。近年来,大量的实验和临床研究证明,该药具有高度抗病毒活性,尤其对疱疹病毒感染。本文拟就国外对该药的研究近况作一扼要综述。 Acyclovir (ACV) is a new synthetic antiviral, also known as acyclo guanosine, open chain guanosine, chemical name 9 [(2-hydroxyethoxy) methyl] Guanine, a guanine derivative with an acyclic side chain at position 9, is structurally 2-deoxyguanosine. In recent years, a large number of experimental and clinical studies have shown that the drug has a high antiviral activity, especially for herpes virus infection. This article is going to make a brief summary of the current situation of the research on this medicine abroad.