基质金属蛋白酶(matrix metalloproteinases,MMPs)是一类结构与氨基酸组成相似,依赖锌离子的蛋白水解酶,迄今为止已经发现了26种[1]。新生儿缺氧缺血性脑病(HIE)是指在围产期缺氧窒息导致的脑组织缺氧缺血性损害。其在围产期神经系统疾病中占重要位置。近年来MMPs与HIE的关系逐 Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes whose structure is similar to that of amino acids and depend on zinc ion. To date, 26 kinds of MMPs have been found [1]. Neonatal hypoxic-ischemic encephalopathy (HIE) is the hypoxic-ischemic brain damage caused by hypoxia asphyxiation during perinatal period. It plays an important role in the perinatal nervous system disorders. The relationship between MMPs and HIE in recent years