论文部分内容阅读
目的:探讨使用普通肝素(UFH)和低分子肝素(LMWH)抗凝治疗所致的血小板减少症(HIT)的临床诊断和治疗方法。方法:回顾性分析应用UFH和LMWH抗凝治疗所致HIT患者7例的临床表现及治疗。结果:发生HIT 7例,血小板降低时间为应用UFH后2~9 d,中位时间4 d;最低(20.00~41.00)×109/L,下降幅度44.44%~91.90%,平均为(78.76±17.05)%。其中2例患者发生血栓栓塞症状。血小板恢复正常时间7~28 d,中位数9 d。结论:HIT可导致血栓栓塞等严重后果,UFH和LMWH抗凝治疗时需常规监测血小板计数,早期诊断和正确治疗可降低致死率和致残率。
Objective: To investigate the clinical diagnosis and treatment of thrombocytopenia (HIT) caused by unfractionated heparin (UFH) and low molecular weight heparin (LMWH) anticoagulant therapy. Methods: The clinical manifestations and treatment of 7 HIT patients with UFH and LMWH anticoagulant therapy were retrospectively analyzed. Results: The incidence of thrombocytopenia was 7 to 14 days after HIFU and the median time was 4 days. The lowest was (20.00 ~ 41.00) × 109 / L, and the decrease was 44.44% ~ 91.90%, with an average of (78.76 ± 17.05) )%. Two of these patients developed thromboembolic symptoms. Platelet recovery time of 7 ~ 28 d, the median 9 d. Conclusion: HIT can lead to serious consequences such as thromboembolism. UFH and LMWH need regular monitoring of platelet count during anticoagulation therapy. Early diagnosis and correct treatment can reduce mortality and morbidity.