【摘 要】
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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor neurons. Most ALS cases are sporadic, but approximately 5–10％ of patients have a familial background. To dat
【机 构】
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Department of Molecular Pathology,Tokyo Medical University,Tokyo,Japan
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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor neurons. Most ALS cases are sporadic, but approximately 5–10％ of patients have a familial background. To date, more than 30 familial ALS-causative genes have been identified (Maurel et al., 2018). The clinical manifestation and disease progression of sporadic ALS and familial ALS are similar and often clinically and pathologically indistinguishable, suggesting that they share a common pathophysiology in motor neuronal degeneration.
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