研究了季铵盐催化合成甲基-1605的反应动力学。导出了反应的速度方程为萃取常数E值的大小决定了反应的动力学特征。将相转移催化条件下与均相条件下反应的二级速度常数进行比较,证实了相转移离子对是水合的。在本反应中,相转移催化作用仅在于加大了亲核试剂在有机相的溶解性。 The reaction kinetics of methyl-1605 catalyzed by quaternary ammonium salt was studied. The velocity equation of the reaction is derived as the value of the extraction constant E, which determines the kinetic characteristics of the reaction. The second-order velocity constants of the reaction under phase-transfer catalysis under homogeneous conditions were compared to confirm that the phase-transfer ion pair is hydrated. In this reaction, the phase transfer catalysis simply increases the solubility of the nucleophile in the organic phase.