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肿瘤的侵袭和转移是一个复杂的病理过程,多种蛋白酶在这一过程中发挥着重要作用,包括基质金属蛋白酶及纤溶酶原系统等,其介导细胞外基质的降解及细胞膜蛋白的水解活化而促进肿瘤细胞的转移。新发现的一种丝氨酸蛋白酶——Matriptase是胰蛋白酶样Ⅱ型跨膜丝氨酸蛋白酶,其表达于许多上皮起源的正常及恶性肿瘤组织中。研究发现,Matriptase具有很强的癌基因潜能,可能参与肿瘤浸润和转移过程。综述Matriptase的基因结构、功能及其与妇科恶性肿瘤的关系。
Tumor invasion and metastasis is a complex pathological process, a variety of proteases play an important role in this process, including the matrix metalloproteinases and plasminogen system, which mediates the degradation of extracellular matrix and the hydrolysis of cell membrane proteins Activation and promote the transfer of tumor cells. A newly discovered serine protease, Matriptase, is a trypsin-like transmembrane serine protease type II that is expressed in many epithelial-derived normal and malignant tumor tissues. The study found that Matriptase has a strong oncogenic potential that may be involved in tumor invasion and metastasis. This review summarizes the gene structure and function of Matriptase and its relationship with gynecological malignancies.