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目的 :观察碱性成纤维细胞生长肽 (bFGF)治疗新生儿缺氧缺血性脑病 (HIE)的疗效及远期随访。方法 :对 12 6例HIE患儿在传统治疗基础上随机分为bFGF治疗组 76例 ,对照组 5 0例。治疗组给予bFGF2 0 0 0IU/d静滴 ,10 - 14天为一疗程 ,观察HIE患儿临床症状消失时间及远期预后随访。结果 :bFGF治疗组显效率 ,总有效率均明显高于对照组 (P <0 .0 1及P <0 .0 5 ) ,后遗症的发生率低于对照组 (P <0 .0 5 ) ,差异有显著意义。结论 :bFGF治疗HIE ,可有效减轻临床症状 ,改善预后 ,减少后遗症的发生。
Objective: To observe the efficacy and long-term follow-up of basic fibroblast growth peptide (bFGF) in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: A total of 126 children with HIE were randomly divided into bFGF treatment group (76 cases) and control group (50 cases). Treatment group bFGF200IU / d intravenous infusion, 10-14 days for a course of treatment to observe the disappearance of HIE clinical symptoms and long-term follow-up prognosis. Results: The effective rate and total effective rate of bFGF treatment group were significantly higher than those of control group (P0.01 and P0.05), the incidence of sequelae was lower than that of control group (P0.05) The difference is significant. Conclusion: bFGF treatment of HIE can effectively reduce the clinical symptoms, improve the prognosis and reduce the occurrence of sequelae.