通过多种动物行为学测试方法发现氯胺酮能够诱导啮齿类动物快速发育期大脑的大量神经元凋亡导致认知功能障碍。其功能损害表现在空间认知能力,学习记忆能力等多方面。但是,在临床中尚未得到证实,氯胺酮对脑发育的影响成为目前的研究重点,其机制的阐明可能对新生儿麻醉用药剂量的合理选用和新药的开发具有指导意义。 Ketamine has been shown to induce a significant amount of neuronal apoptosis in the rapidly developing brain of rodents resulting in cognitive dysfunction through a variety of animal behavioral testing methods. Its functional impairment is manifested in many aspects such as spatial cognitive ability, learning and memory ability. However, it has not been confirmed clinically that the impact of ketamine on brain development has become the focus of current research. The elucidation of its mechanism may be instructive for rational use of neonatal anesthesia dosage and the development of new drugs.