An inclusion complex (1) has been preparted by cyclodextrin with22.7( )]-aminopyridine. The result of X-[(ray crystallo)(graphic analyses showed that th)]eα-aminopyridine molecules in thecyclodextrin cavities possess two opposite orientations, i.e. the amine group ofα-aminopyridine pointing to the primary side (1a, occupancy:41.2%) of the secondary side (1b, occupancy:58 ofβ-[(cyclodextrin, forming two scaleli)(ke )]supramolecular aggregations. The studies of 2D NMR and circular dichroism spectra indicated that theaminopyridine molecule is deeply embedded in thecyclodextrin cavity to form host-guest inclusion complex, showing a circular dichroism spectrum induced by the chiral cavity of cyclodextrin. The results obtained are helpful for understanding [(the molecular recognition and aggregation mechanism between the host and guest. The inclusion of cyclodextrin with 22.7 ()] - aminopyridine. The result of X - [(ray crystallo) (graphic analyzes showed that th)] eα-aminopyridine molecules in thecyclodextrin cavities possess two opposite orientations, ie the amine group of α-aminopyridine pointing to the primary side (1a, occupancy: 41.2%) of the secondary side (1b, occupancy: 58 of β - [(cyclodextrin, forming two scaleli) (ke)] supramolecular aggregations. 2D NMR and circular dichroism spectra indicated that the aminopyridine molecule is deeply embedded in thecyclodextrin cavity to form host-guest inclusion complex, showing a circular dichroism spectrum induced by the chiral cavity of cyclodextrin. The results obtained are helpful for understanding [(the molecular recognition and aggregation mechanism between the host and guest.