早在1924年Letterer首次报告了本病,Siwe于1933年搜集了文献3例,加上他本人观察的1例,最早确定了本病的临床和解剖方面的一些特征。1936年Abt和Denenholz将本病命名为勒—雪氏病。勒—雪氏病是一种少见的分化较好的组织细胞呈急性进行性增生的疾病。临床上以长期反复发热,皮疹,肝脾淋巴结肿大,肺部润浸,骨骺缺损为特征,并常伴有进行性 As early as 1924, Letterer first reported the disease, and Siwe collected 3 articles in 1933. In addition, the 1 case he observed himself first identified some clinical and anatomical features of this disease. In 1936 Abt and Denenholz named the disease Lehler’s disease. Leh-Schue disease is a rare, well-differentiated tissue cell that is acutely proliferative. Clinical long-term repeated fever, rash, hepatosplenomegaly, pulmonary infiltration, epiphyseal defect is characterized by, and often accompanied by progressive