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目的分析血清C肽水平与2型糖尿病患者血脂控制及心脑血管并发症关系。方法选取临沂市第三人民医院收治的2型糖尿病患者667例,对其临床资料进行回顾性分析,根据血清C肽水平进行分组,血清C肽≥1.1ng/ml者为正常组,血清C肽<1.0ng/ml者为低肽组,比较两组患者血脂控制水平及心脑血管并发症发生情况,分析其相关性。结果正常组患者TC、HDL-C、LDL-C水平均低于低肽组,肌酐水平高于低肽组,差异均有统计学意义(P<0.05)。正常组患者TG水平与低肽组比较,差异无统计学意义(P>0.05)。正常组冠心病占7.11%,脑梗死占10.67%,低肽组冠心病占22.75%,脑梗死占19.58%,正常组冠心病、脑梗死占的比例均低于低肽组,差异均有统计学意义(P<0.05)。结论血清C肽水平与2型糖尿病患者血脂水平有密切的联系,可能导致患者血脂紊乱,同时患者心脑血管并发症发生率也会受到血清C肽水平的影响。
Objective To analyze the relationship between serum C-peptide level and blood lipid control and cardiovascular and cerebrovascular complications in type 2 diabetic patients. Methods A total of 667 type 2 diabetic patients were enrolled in the Third People’s Hospital of Linyi City. The clinical data of the patients were retrospectively analyzed. According to the level of serum C-peptide, serum C-peptide≥1.1ng / ml was normal group, serum C-peptide <1.0ng / ml for the low peptide group, comparing the two groups of patients with lipid levels of control and cardiovascular complications, analysis of their relevance. Results The levels of TC, HDL-C and LDL-C in the normal group were significantly lower than those in the low-peptide group and creatinine levels were higher than those in the low-peptide group (P <0.05). TG levels in patients with normal group compared with low peptide group, the difference was not statistically significant (P> 0.05). Coronary heart disease accounted for 7.11% of the normal group, cerebral infarction accounted for 10.67%, low peptide group of coronary heart disease accounted for 22.75%, cerebral infarction accounted for 19.58%, the normal group of coronary heart disease, cerebral infarction accounted for less than the proportion of low peptide group, the difference was statistically Significance (P <0.05). Conclusions Serum C-peptide levels are closely related to the level of serum lipids in type 2 diabetic patients, which may lead to dyslipidemia. The incidence of cardiovascular and cerebrovascular complications in patients with type 2 diabetes mellitus is also affected by serum C-peptide levels.