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目的 探讨支气管哮喘的发病机理。方法 对 2 3例哮喘患者及 2 0例正常人用ELISA法测定其血清中可溶性粘附分子sE selectin的含量 ,采用荧光免疫法 ,测定其血清总IgE(tIgE)、特异性IgE(sIgE)和嗜酸性粒细胞阳离子蛋白 (ECP) ,并作相关性分析。结果 哮喘组的sE selectin和tIgE血清含量与对照组相比 ,差异有高度显著性 (P <0 .0 0 1)多因素相关性分析提示 :sE selectin与tIgE存在直线正相关 (r=0 .6 6 4,P <0 .0 0 2 ) ;蒿草花粉、屋尘螨、屋尘及草花粉的血清sIgE水平较高 ,为引起哮喘发病的主要变应原 ;哮喘急性发作期的血清ECP水平明显高于缓解期 (P <0 .0 0 1)。结论 哮喘患者血清可溶性粘附分子sE selectin和IgE较正常人高 ,且存在直线正相关 ;我国北方地区引起哮喘的常年性变应原为屋尘螨和屋尘 ,而夏秋季的主要变应原是蒿草花粉和草花粉 ;血清ECP含量在哮喘发作期较缓解期高 ,这可能与嗜酸性粒细胞处于活化状态有关
Objective To investigate the pathogenesis of bronchial asthma. Methods Serum total soluble estrogen receptor sE selectin was detected by ELISA in 23 asthmatic patients and 20 normal individuals. The serum total IgE (tIgE), specific IgE (sIgE) and Eosinophil cationic protein (ECP), and make correlation analysis. Results The serum levels of sE selectin and tIgE in the asthma group were significantly higher than those in the control group (P <0.001). The multivariate correlation analysis showed that there was a linear positive correlation between sE selectin and tIgE (r = 0. 6 6, P <0 0 2 2). The serum sIgE levels of wormwood pollen, house dust mite, house dust and hay fever pollen were high, which were the major allergens causing asthma. Serum The level of ECP was significantly higher than that of remission (P <0. 001). Conclusion The serum soluble adhesion molecules sE selectin and IgE in asthma patients are higher than those in normal people, and there is a linear positive correlation. The perennial allergens that cause asthma in northern China are house dust mite and house dust, while the main allergens Is the wormwood pollen and hay fever pollen; serum ECP levels in the asthma attack period is higher than the remission, which may be associated with eosinophil activation