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目的探讨降钙素原(PCT)、C-反应蛋白(CRP)对儿童细菌感染性肺炎的早期诊断和预后判断的价值。方法选择在本院接受治疗的70例细菌感染性肺炎儿童为细菌感染组,选取70例非细菌感染性肺炎儿童为非细菌感染组,另取70例健康儿童为非感染组。收集各组患儿痰液进行培养,于治疗前测定3组儿童C-反应蛋白(CRP)水平及白细胞计数(WBC)、血沉(ESR)等炎性指标。结果细菌感染性肺炎患儿PCT和CRP含量明显高于非细菌感染性肺炎组和非感染组(P<0.05),细菌感染性肺炎组患儿CRP及PCT含量在痰培养阳性组中的表达量显著高于痰培养阴性组(P<0.05),细菌感染性肺炎患儿治愈组入院时CRP及PCT含量明显低于未治愈组(P<0.05)。结论 CRP及PCT能在一定程度上早期诊断儿童细菌感染性肺炎并预测痰培养结果及治疗结局,具有一定的临床价值。
Objective To investigate the value of procalcitonin (PCT) and C-reactive protein (CRP) in the early diagnosis and prognosis of bacterial pneumonia in children. Methods Seventy patients with bacterial pneumonia admitted to our hospital were selected as bacterial infection group. Seventy children with non-bacterial pneumonia were selected as non-bacterial group and 70 healthy children as non-infected group. The sputum of children were collected and cultured. The levels of C-reactive protein (CRP), white blood cell count (WBC) and erythrocyte sedimentation rate (ESR) in 3 groups of children before treatment were measured. Results The contents of PCT and CRP in children with bacterial pneumonia were significantly higher than those in non-bacterial pneumonia group and non-infected group (P <0.05). The expression levels of CRP and PCT in children with bacterial pneumonia were significantly higher in sputum culture-positive group (P <0.05). CRP and PCT levels in the children with bacterial pneumonia were significantly lower than those in the untreated group (P <0.05). Conclusion CRP and PCT can be used to diagnose bacterial pneumonia in children early and to predict sputum culture outcome and treatment outcome. It has certain clinical value.