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研究加减血癥汤体内抗移植性肿瘤的作用及其参与肿瘤的凋亡、侵袭、转移等恶性生物学行为,为加减血癥汤的临床应用提供理论依据.方法:加减血癥汤醇提液灌饲接种过人胃癌SGC-7901细胞的荷瘤小鼠,并通过测定其抑瘤率、瘤体免疫组化检测VEGF、HIF-lα、CD31蛋白表达来进一步探讨其抗瘤活性作用.结果:不同剂量加减血癥汤具有抗人胃癌SGC-7901移植性肿瘤的作用,抑瘤率达60％、37％、31％,同时可以下调VEGF、HIF-1α、CD31蛋白表达.结论:加减血癥汤具有较强的抗肿瘤的作用,可能与下调VEGF、HIF-1α、CD31蛋白表达有关.“,”Objective:To investigate the anti-tumor effects of Modified Xuezheng Decoction in vivo and the malignant biological behavior of tumor invasion and metastasis,and provide basic theory for clinical application.Methods:SGC-7901 tumor bearing mice orally were given alcohol extract of Modified Xuezheng Decoction.and the anti-tumor activity was investigated by determining its tumor inhibiting rate and immunohistochemical detection of the protein expression of VEGF,HIF-1αand CD31.Results:The different dosage of Modified Xuezheng Decoction can significantly inhibit SGC-7901 tumor cell's growing,the inhibiting rate reached 60％,37％ and 31％,and reduced the protein expression of VEGF,HIF-1α and CD31.Conclusion:Modified Xuezheng Decoction has strong anti-tumor activity and the therapeutic effect may be associated with the reduction of VEGF,HIF-1αand CD31 expression in tumor.