胰岛素自身免疫综合征（ＩＡＩＳ）临床极为少见。常因精神症状、癫痫样发作、意识障碍等就诊于神经科，若考虑不到本征，易造成误诊。我院收治２例，现报告如下。１　病例介绍例１，男，７４岁。因烦躁不安、胡言乱语３０ｍｉｎ入院。无糖尿病及胰岛素注射史。查体：神志恍惚 Insulin autoimmune syndrome (IAIS) clinically rare. Often due to mental symptoms, epileptic seizures, disturbance of consciousness and other treatment in neurology, if not consider the intrinsic, easy to cause misdiagnosis. 2 cases admitted to our hospital, are as follows. A case introduction example 1, male, 74 years old. Because of irritability, nonsense 30min admission. No history of diabetes and insulin injections. Physical examination: mind trance