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目的:探讨长期住院女性精神病患者肥胖与血清胰岛素、C肽水平的关系。方法:将104例长期住院女性精神病患者按体重指数分为肥胖组52例和非肥胖组52例,以50例健康者作为对照组,检测空腹血糖(FPG)、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的水平,同时采用微粒子化学发光法测定血清胰岛素、C肽,以稳态模型评估法评价胰岛素抵抗指数。结果:肥胖组和非肥胖组血清胰岛素、C肽水平和HOMA-IR均高于健康对照组(P<0.05),且肥胖组亦高于非肥胖组(P<0.01)。相关性显示肥胖组血清胰岛素和HOMA-IR与BM I、WHR、C肽、TG、LDL-C水平呈明显正相关(P<0.05)。结论:女性精神病患者,特别是肥胖者,存在IR、高胰岛素血症。因及早采取行之有效的干预方法防止并发症发生。
OBJECTIVE: To investigate the relationship between obesity and serum insulin and C-peptide levels in long-term female mental patients. Methods: A total of 104 long-term hospitalized female patients with mental illness were divided into two groups based on body mass index (BMI): obesity group (52 cases) and non-obese group (52 cases). Fifty healthy subjects were used as control group. FPG, TC, (TG), HDL-C and LDL-C, and serum insulin and C-peptide were determined by the method of microparticle chemiluminescence Insulin resistance index. Results: The levels of insulin, C-peptide and HOMA-IR in obese and non-obese patients were significantly higher than those in healthy controls (P <0.05), and were also higher in obese and non-obese groups than in non-obese patients (P <0.01). The correlation between serum insulin and HOMA-IR and BM I, WHR, C-peptide, TG and LDL-C in obesity group showed a significant positive correlation (P <0.05). Conclusion: Female psychopaths, especially obese, have IR and hyperinsulinemia. Because of early effective interventions to prevent complications.