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微阵列比较基因组杂交(array-CGH)技术是将DNA克隆或cDNAs做成微阵列,代替传统CGH法中中期染色体作为杂交靶,不仅使分辨率提高,甚至可以确定肿瘤相关基因并提供精确的定位。全文综述Array-CGH的原理、方法及其在肿瘤学中的应用和意义。
The array-CGH technique, which uses microarray arrays or cDNAs as microarrays to replace the metaphase chromosomes in traditional CGH as a hybridization target, not only improves the resolution but also allows the identification of tumor-associated genes and provides precise localization . The full text summarizes the principle and method of Array-CGH and its application and significance in oncology.