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内皮祖细胞是来源于骨髓可分化为内皮细胞的一群细胞,在组织缺血及血管损伤时动员入血,参与微血管的生成及血管内皮的修复。有研究表明循环内皮祖细胞的数量和功能与冠心病危险因子呈负相关,提示循环内皮祖细胞有作为心血管疾病预后评估工具的应用前景。他汀类药物除了调节血脂的作用外,在血脂正常的动物模型中也发现能增加内皮祖细胞数量及增强内皮祖细胞功能,他汀类药物的这种作用可能是其临床上治疗冠心病获益的机制之一。
Endothelial progenitor cells are a group of cells derived from bone marrow that can differentiate into endothelial cells. They mobilize into the blood during tissue ischemia and vascular injury, and are involved in the formation of microvessels and the repair of vascular endothelium. Studies have shown that the number and function of circulating endothelial progenitor cells and coronary heart disease risk factors was negatively correlated, suggesting that circulating endothelial progenitor cells as a prognostic tool for cardiovascular disease prospects. In addition to regulating blood lipids, statins have also been found to increase the number of endothelial progenitor cells and enhance endothelial progenitor function in animal models of hyperlipidemia. This statin effect may be attributable to its clinical benefit in treating coronary heart disease One of the mechanisms.