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在乙型肝炎病毒(HBV)基因区中有4个开放读码框架,分别是前S/S,前C/C,P和X基因区。前C/C基因区与HBeAg的合成和分泌密切相关。前C基因区启始密码子(ATG)可连续启动前C和C基因,共同编码一个P_(25)多肽,该P_(25)多肽也称HBeAg前体,在肝细胞内质网膜被酶降解成p_(17)多肽,此即HBeAg,并以游离形式释放到血消冲。由于前C基因区第1896位和(或)1899位核苷酸发生点突变,原来的鸟嘌呤(G)被腺嘌呤(A)所取代(G→A,点突变),使密码子由TGG转为TAG,结果在前C基因区的
There are four open reading frames in the Hepatitis B virus (HBV) gene region, pre-S / S, pre-C / C, P and X gene regions. The pre-C / C gene region is closely related to the synthesis and secretion of HBeAg. The pre-C gene start codon (ATG) initiates the pre-C and C genes in tandem and encodes a P25 polypeptide, also known as the HBeAg precursor, in the hepatocyte endoplasmic reticulum by the enzyme Degradation into p_ (17) polypeptide, which is HBeAg, and released to the blood in the free form Chong Chong. The original guanine (G) was replaced by adenine (A) (point G → A) due to the site-directed mutagenesis at position 1896 and / or 1899 of the pre-C gene region, allowing codons to be replaced by TGG Transferred to TAG, the result in the pre-C gene region