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探讨胆囊癌患者的免疫状态及其对结石在胆囊癌发病机理中的作用，采用散射浊光计免疫法检测了单纯胆囊癌、伴胆石胆囊癌、胆石症患者和健康人的血清补体和免疫球蛋白水平，并采用双抗体夹心ＥＬＩＳＡ法测定了上述各组血清Ｔ淋巴细胞亚群、胆汁和血清中的白细胞介素２（ＩＬ２）和可溶性白细胞介素２受体（ｓＩＬ２Ｒ）的水平。结果显示，单纯胆囊癌及伴胆结石胆囊癌患者的细胞免疫受抑制，其ＣＤ＋４细胞和ＩＬ２水平较正常对照组低，ＣＤ＋８细胞和ｓＩＬ２Ｒ水平明显增高，且与胆囊癌的临床分期相关。胆结石患者与伴胆结石胆囊癌相比，其ＣＤ＋４细胞、ＩＬ２水平较高，ＣＤ＋８细胞和ｓＩＬ２Ｒ水平较低。本实验结果提示：①胆囊癌患者处于免疫抑制状态；②在伴胆结石胆囊癌的发病过程中，胆结石作为一种慢性损伤和刺激，促使了ＣＤ＋４、ＣＤ＋８细胞之间的平衡及ＩＬ２及其受体之间的平衡失调；③动态检测Ｔ淋巴细胞及ｓＩＬ２Ｒ水平可作为判断胆囊癌病情有价值的参考指标。
To investigate the immune status of gallbladder cancer patients and their role in the pathogenesis of gallbladder carcinoma. Serum complement and immunoglobulins were measured in patients with gallbladder carcinoma, gallbladder gallbladder carcinoma, cholelithiasis, and healthy people by using a scattering turbidimeter immunoassay. At the protein level, serum T lymphocyte subsets, bile and serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) were measured by double antibody sandwich ELISA. )s level. The results showed that the cellular immunity of patients with gallbladder carcinoma and cholecystolithiasis was inhibited, and the levels of CD+4 cells and IL 2 were lower than those in normal controls, and the levels of CD+8 cells and sIL 2R were significantly higher, and the clinical stage of gallbladder cancer was also shown. Related. Patients with gallstones had higher levels of CD+4 cells and IL-2 than gallstones with gallstones, and CD+8 cells and sIL-2R levels were lower. The results of this experiment suggest that: 1 gallbladder cancer patients are in immunosuppressed state; 2 gallstones as a chronic injury and stimulation in the pathogenesis of gallbladder gallstone carcinoma, promoted the balance between CD+4, CD+8 cells and IL 2 Disequilibrium between its receptor and its receptor;3 Dynamic detection of T lymphocyte and sIL-2R levels can be used as a valuable index to judge the condition of gallbladder cancer.