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乳腺癌患者若在近亲中有多人发病,或双侧乳腺发病,或在幼年发病,均可成为明显增加乳腺癌发病危险的单一因素。这种危险可能是由于社会、饮食或环境因素增加了乳腺癌的易感性,或遗传因素增加了乳腺癌的易感性。在某些家系中,乳腺癌的模型是否与“乳腺癌易感性”基因的孟德尔式分离律相符;或该基因实际上是否与一个已知的、遗传上已标记的位点相连锁,目前尚未确定。作者调查了11个应征或自愿的家系登记簿以作癌症遗传学的研究。作者假设这些家族乳腺癌发病率高,并测定了这些升高的发病率和预期遗传上受影响的疾病的一致性。为了测定那些最适合于观察的乳腺
Breast cancer in the close relatives of many people in the incidence, or bilateral breast disease, or in infancy, can significantly increase the risk of breast cancer a single factor. This risk may be due to social, dietary or environmental factors that increase the susceptibility of breast cancer, or genetic factors increase the susceptibility of breast cancer. In some families, is the model of breast cancer consistent with the Mendelian law of segregation of “breast cancer susceptibility” genes; or is the gene actually linked to a known, genetically-tagged site that is currently not sure yet. The authors investigated 11 applications for or voluntary family register for cancer genetics research. The authors hypothesized that these families have a high incidence of breast cancer and determined the coincidence of these elevated incidences and the diseases that are expected to be genetically affected. In order to determine those most suitable for observation of the breast