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目的:观察硫普罗宁治疗非酒精性脂肪肝的疗效。方法:将104例非酒精性脂肪肝患者随机分为2组:治疗组52例,给予硫普罗宁治疗;对照组52例,给予护肝片治疗。疗程均为3个月。检测2组治疗前后血清氨基转移酶、血脂等指标。结果:治疗组在降低丙氨酸氨基转移酶、天门冬酸氨基转移酶及总胆固醇、三酰甘油方面明显优于对照组(P<0.05);治疗组与对照组总有效率分别为92.3%、65.4%,2组比较有非常显著性差异(P<0.01)。结论:硫普罗宁治疗非酒精性脂肪肝安全、有效。
Objective: To observe the efficacy of tiopronin in the treatment of non-alcoholic fatty liver. Methods: 104 patients with non-alcoholic fatty liver were randomly divided into two groups: the treatment group, 52 cases given tiopronin treatment; control group, 52 cases, given liver tablets treatment. Treatment are 3 months. The serum aminotransferase, blood lipid and other indexes of two groups before and after treatment were detected. Results: The treatment group was significantly better than the control group in reducing alanine aminotransferase, aspartate aminotransferase and total cholesterol, triglyceride (P <0.05); the total effective rate of the treatment group and the control group were 92.3% , 65.4%, there was a significant difference between the two groups (P <0.01). Conclusion: Tiopronin is safe and effective in treating non-alcoholic fatty liver disease.