阿托品是一种较为古老的药物,自1809年被发现以来,已有170余年的历史。虽然,早在1867年即已证明其抗迷走神经作用,1912年已认识到它对心律的影响;但直至近代,阿托品用于诊断窦房结功能不全及治疗急性心肌梗塞并发心动过缓——低血压综合征之后,此药的心血管作用才越来越为临床所重视。本文略述其药理学、及电生理学;并着重将其在心血管疾病中的应用予以叙述。 Atropine is a more ancient drug that has been in existence for more than 170 years since it was first discovered in 1809. Although its anti-vagal effect has been proven since 1867, its effect on heart rate has been recognized in 1912; until recently, atropine was used to diagnose sinus node dysfunction and to treat acute myocardial infarction complicated with bradycardia-low Blood pressure syndrome, the drug’s cardiovascular role is more and more clinically important. This article outlines its pharmacology, and electrophysiology; and focuses on its application in cardiovascular disease is described.