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许多文章提出孕妇使用外源性孕激素对胎儿发育有不利影响,尤其注意到女性生殖器男性化、尿道下裂、心血管畸形和VACTERL(一种影响骨骼、消化、呼吸和肾系统的多发性畸形).另一些报告孕激素与胎儿发育障碍无关.由于所用的药物不同,使这些报告难以比较.有些药已知有雄激素活性,有的可代谢为具有不同激素活性的甾类.此外,合用过雌、孕激素的胎儿常被归纳在单用孕激素的一组中,可能有些认为是黄体制剂的作用实际上是其他激素活性或激素联合作用的结果.
Many articles suggest that the use of exogenous progestins in pregnant women adversely affects fetal development, noting in particular the masculine genitalia, hypospadias, cardiovascular malformations and VACTERL (a multiple deformity affecting the bones, digestive, respiratory and renal systems Other reports that progesterone has nothing to do with fetal developmental disorders make these reports difficult to compare due to the different drugs used.Some drugs are known to be androgen metabolites and some may be metabolized to steroids with different hormone activities.In addition, Oesome, progesterone fetuses are often grouped into the group of progestins alone, and some may think that the effects of luteinizing agents are actually the result of other hormonal or hormonal combinations.