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目的 探讨蛛网膜下腔出血 (SAH)后体感诱发电位 (SEP)、血清及脑组织一氧化氮 (NO)含量变化。方法 对假手术对照组和模型组大鼠检测 2 4h内局部脑血流量 (rCBF)、SEP和血清及脑组织NO含量。结果 模型组SAH后rCBF立即降低 ,在 2 4h内无恢复趋势 ;SEP潜伏期于SAH后 1～ 2 4h明显延长 ;血清和脑组织NO含量于SAH后 1h开始分别显著减少和明显增加 ,并持续 2 4h。结论 SEP对SAH后脑缺血损害的判断有重要意义。血清NO减少、脑组织NO增加分别在脑血管痉挛发生及加重脑缺血损害中起重要作用。
Objective To investigate the changes of somatosensory evoked potential (SEP), serum and brain tissue nitric oxide (NO) after subarachnoid hemorrhage (SAH). Methods The sham operation control group and model group rats were given local cerebral blood flow (rCBF), SEP and serum and brain NO content within 24 hours. Results The rCBF decreased immediately after SAH in model group and did not recover within 24 hours. The latency of SEP was prolonged 1 ~ 24 hours after SAH. The content of NO in serum and brain tissue significantly decreased and significantly increased from 1 hour after SAH, and continued for 2 4h. Conclusions SEP is of great significance in judging the cerebral ischemic damage after SAH. Reduced serum NO, increased NO in brain tissue play an important role in the occurrence of cerebral vasospasm and aggravate cerebral ischemia.