用3-甲基胆蒽(3-MC)诱发大鼠肺癌前病变,并观察癌变过程中γ-谷氨酰转肽酸(GGT)的组织化学反应。结果支气管内1次灌注3-MC(3mg/100g体重)30d后,大鼠小支气管上皮不典型增生、腺样增生与腺癌及鳞癌的发生率分别为88.2％、70.6％及17.7％,60d的发生率分别为83.3％、23.5％及38.9％,且上述病变均呈GGT染色阳性反应,提示GGT可作为肺癌前病变的标志酶之一。 Rats with precancerous lesions were induced with 3-methylcholanthrene (3-MC) and histochemical reactions of γ-glutamyl transpeptidic acid (GGT) during the carcinogenesis were observed. Results The incidence of atypical hyperplasia, adenoid hyperplasia, adenocarcinoma, and squamous cell carcinoma in small bronchial epithelium was 88.2%, 70.6%, and 17.7% respectively after 30 days of intrabronchial instillation of 3-MC (3 mg/100 g body weight). The incidence of 60d was 83.3%, 23.5%, and 38.9%, respectively, and the above lesions were positive for GGT staining, suggesting that GGT may be one of the marker enzymes of precancerous lesions.