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1,6-二磷酸果糖(FDP)为糖代谢过程重要的中间产物,能改善心肌能量代谢,还具有稳定细胞膜、减轻炎性反应、抑制氧自由基,降低细胞外Ca 2+浓度,抑制心律失常等作用,在动物实验和临床研究方面取得了良好的结果。本文对FDP对缺血保护机制和研究进展作一综述。
Fructose-1,6-diphosphate (FDP) is an important intermediate product of glucose metabolism, which can improve myocardial energy metabolism, stabilize cell membrane, reduce inflammatory reaction, inhibit oxygen free radicals, decrease extracellular Ca 2+ concentration and inhibit heart rhythm Disorders and other effects, in animal experiments and clinical studies have achieved good results. This article reviews the mechanism of FDP ischemia protection and research progress.