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目的：对两性霉素Ｂ（ＡｍＢ）在５０ｇ·Ｌ－１葡萄糖注射液中的稳定性进行实验考察。方法：将０．０５，０．１，０．１５ｇ·Ｌ－１３种浓度ＡｍＢ的５０ｇ·Ｌ－１葡萄糖注射液在８℃冷藏、２５℃及３４℃光照及避光５种贮存条件下放置２４ｈ，观察３种浓度稀释液的外观及含量变化。结果：５种贮存条件下放置２４ｈ，３种稀释液均无外观改变和明显的ｐＨ变化。与初浓度比较：在８℃冷藏贮存２４ｈ，３种稀释液的ＡｍＢ含量下降小于２％，光照下２５℃２４ｈ及３４℃１２ｈ，ＡｍＢ含量下降均已大于１０％，２５℃及３４℃避光条件下２４ｈＡｍＢ含量下降低于１０％。结论：两性霉素Ｂ的５０ｇ·Ｌ－１葡萄糖注射液在光照下不稳定。在避光条件下对通常的室温温度（２５℃～３４℃）则较稳定。临床使用ＡｍＢ滴注时必须临时配制，避光滴注。
Objective: To investigate the stability of amphotericin B (AmB) in 50g · L-1 glucose injection. Methods: 50g · L-1 dextrose injection with the concentrations of 0.05,0.1,0.15g · L-13 AmB was stored at 8 ℃, 5 ℃, 25 ℃ and 34 ℃ under light and dark conditions 24h, observe the appearance of three kinds of concentration dilution and content changes. Results: Under the five storage conditions for 24h, none of the three dilutions showed any change in appearance and significant pH change. Compared with the initial concentration, the AmB content of the three kinds of dilutions decreased by less than 2% at 8 ℃ for 24h, and the AmB content decreased by more than 10% at 25 ℃ for 24h and 34 ℃ for 12h, 25 ℃ and 34 ℃ 24hAmB content decreased less than 10%. Conclusion: Amphotericin B 50g · L-1 glucose injection is unstable under light irradiation. In the dark conditions of the normal room temperature (25 ℃ ~ 34 ℃) is more stable. Clinical use of AmB must be temporarily formulated drip, dark instillation.