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目的研究锌对急性镉中毒性肾损伤的保护作用。方法给大鼠腹腔注射ＣｄＣｌ２（１５μｍｏｌ／ｋｇ）与巯基乙醇（３００μｍｏｌ／ｋｇ，ｍｅｒｃａｐｔｏｅｔｈａｎｏｌ，ＭＥ）混合染毒液的同时，皮下注射锌（ＺｎＳＯ４１５μｍｏｌ／ｋｇ）。结果加锌能明显降低肾皮质镉含量，同时亦使肾线粒体、胞浆中铁含量下降，锌含量升高，并可使染镉后２小时本应增加的脂质过氧化反应有所抑制，但在４小时后作用消失，使ＳＯＤ活性显著升高；但对肾功能及超微结构的改善则不明显。结论氧自由基损伤可能是镉中毒性肾损伤的主要机制，锌对镉中毒性肾损伤的拮抗作用不明显，是否与剂量等因素有关，尚待进一步研究。
Objective To study the protective effect of zinc on acute cadmium poisoning renal injury. Methods Rats were intraperitoneally injected with CdCl2 (15μmol / kg) and mercaptoethanol (ME) mixed solution at the same time, Zn (15μmol / kg) was injected subcutaneously. Results Adding zinc could significantly reduce the content of cadmium in the renal cortex, meanwhile, the content of iron in the mitochondria and cytoplasm of the kidney also decreased and the content of zinc increased, and the lipid peroxidation which should be increased at 2 hours after cadmium was suppressed. Disappeared after 4 hours, the SOD activity was significantly increased; but the improvement of renal function and ultrastructure is not obvious. Conclusions Oxygen free radical injury may be the main mechanism of cadmium-induced renal injury. The antagonistic effect of zinc on cadmium-induced renal injury is insignificant, whether it is related to dose or other factors, and remains to be further studied.