论文部分内容阅读
哮喘患者受到激发刺激极易发生气道狭窄,即支气管高反应性(Bronchial hyperreactivity,BHR),表现为气道的可逆性阻塞。在中枢神经系统的控制下,呼吸功能的反馈作用,植物神经和内分泌系统的内环境稳定作用(homeostasis)都参与BHR的形成,BHR既与免疫反应有关,同时也与神经系统的控制失调有关,是哮喘的病理生理基础。因此BHR是哮喘的一个关键性特征,与炎症密切相关,并且决定疾病的严重程度,因此降低BHR,能够有效地控制哮喘发作。从理论上讲,目前存在以下治疗途径:(1)回避过敏原;(2)脱敏疗法;(3)诱导IgA封闭抗体;(4)抑制IgE抗体产生;(5)抑制FcERI的功能;(6)阻止IgE抗体对靶细胞的致敏作用;(7)抑制肥大细胞、嗜碱粒细胞的增殖;(8)阻止或抑制递质的生成和游离;(9)拮抗递质对靶组织的作用;(10)抑制嗜酸性粒细胞的增殖和功能;(11)抑制脏器的过敏性。
Asthma patients are prone to airway stenosis, stimulated by stimulation, namely, bronchial hyperreactivity (BHR), which manifests as reversible obstruction of the airways. Under the control of the central nervous system, the feedback function of respiratory function, the homeostasis of autonomic nerve and endocrine system are both involved in the formation of BHR. BHR is related to both immune response and nervous system control disorders, Is the pathophysiology of asthma basis. BHR is therefore a key feature of asthma and is closely linked to inflammation and determines the severity of the disease, thus reducing BHR and effectively controlling asthma attacks. In theory, there are currently the following therapeutic approaches: (1) avoidance of allergens; (2) desensitization; (3) induction of IgA blocking antibodies; (4) inhibition of IgE antibody production; (5) inhibition of FcERI function; 6) Preventing sensitization of target cells by IgE antibody; (7) Inhibition of proliferation of mast cells and basophils; (8) Preventing or inhibiting the formation and release of transmitter; (9) Antagonizing the effect of transmitter on target tissue (10) inhibition of eosinophil proliferation and function; (11) inhibition of organ allergy.