Objective:To assess the seasonality of the bacterial meningitis and the antibiotic resistance of incriminated bacteria over the last three years in the northern Togo.Methods:From January 2007 to January 2010,533 cerebrospinal fluids(CSF) samples were collected from patients suspected of meningitis in the Regional Hospital of Dapaong(northern Togo).After microscopic examination,samples were cultured for bacterial identification and antibiotic susceptibility. Results:The study included 533 patients(306 male and 227 female) aged from 1 day to 55 years [average age(13.00±2.07) years].Bacterial isolation and identification were attempted for 254/533 (47.65%) samples.The bacteria]species identified were:Neisseria meningitidis A(N.meningitidis A)(58.27%),Neisseria meningitidis W135(N,meningitidis W135)(7.09%),Streptococcus pneumoniae(S.pneumoniae)(26.77%),Haemophilus influenza B(H.influenza B)(6.30%) and Enterobacteriaceae(1.57%).The results indicated that bacterial meningitis occur from November to May with a peak in February for H.influenzae and S.pneumoniae and March for Neisseriaceae. The distribution of positive CSF with regards to the age showed that subjects between 6 and 12 years followed by subjects of 0 to 5 years were most affected with respective frequencies of 67.82%and 56.52%(P<0.001).Susceptibility tests revealed that bacteria have developed resistance to several antibiotics including aminosides(resistance rate>20%for both bacterial strains),macrolides(resistance rate>30%for H.influenzae) quinolones(resistance rate>15% for H.influenzae and N.meningitidis W135).Over three years,the prevalence of S.pneumoniae significantly increased from 8.48%to 73.33%(P<0.001),while the changes in the prevalence of H.influenzae B were not statistically significant:4.24%,vs.8.89%,(P= 0.233).Conclusions: Our results indicate that data in African countries differ depending on geographical location in relation to the African meningitis belt.This underlines the importance of epidemiological surveillance of bacterial meningitis. Objective: To assess the seasonality of the bacterial meningitis and the antibiotic resistance of incriminated bacteria over the last three years in the northern Togo. Methods: From January 2007 to January 2010,533 cerebrospinal fluids (CSF) samples were collected from patients suspected of meningitis in the Regional Hospital of Dapaong (northern Togo). After microscopic examination, samples were cultured for bacterial identification and antibiotic susceptibility. Results: The study included 533 patients (306 male and 227 female) aged from 1 day to 55 years [average age ( (58.27%), Neisseria meningitidis W135 (N, meningitidis W135), Streptococcus pneumoniae (26.77%), Haemophilus influenza B (6.30%) and Enterobacteriaceae (1.57%). The results indicated that the bacterial meningitis occurred from Nov ember to May with a peak in February for H. influenzae and S. pneumoniae and March for Neisseriaceae. The distribution of positive CSF with regards to the age showed that subjects between 6 and 12 years followed by subjects of 0 to 5 years were most affected (P <0.001). Susceptibility tests showed that bacteria have developed resistance to several antibiotics including aminosides (resistance rate> 20% for both bacterial strains), macrolides (resistance rate> 30% for H. pylori) influenzae) quinolones (resistance rate> 15% for H. influenzae and N. meningitidis W135) .Over three years, the prevalence of S.pneumoniae significantly increased from 8.48% to 73.33% (P <0.001), while the changes in the prevalence of H. influenzae B were not significantly significant: 4.24%, vs.8.89%, (P = 0.233) .Conclusions: Our results indicate that data in African countries differ depending on geographical location in relation to the African meningitis belt.This underlines the importance of epid emiological surveillance of bacterial meningitis.