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研究四逆汤复方环境中乌头生物碱的体内吸收动力学特征。运用大鼠肝门静脉和颈静脉双位点插管技术取血,采用HPLC测定血浆中乌头碱、新乌头碱、次乌头碱,求算表观吸收系数,分析四逆汤喷干粉中3种乌头生物碱在大鼠体内的吸收动力学特征。结果显示,四逆汤喷干粉中新乌头碱、乌头碱、次乌头碱的表观吸收系数分别为0.336,0.090,0.176,新乌头碱的体内吸收程度优于乌头碱和次乌头碱。结果表明,肝门静脉和颈静脉双位点插管技术是一种研究药物肠道吸收的有效方法。大鼠灌胃四逆汤喷干粉后,3种乌头生物碱均可吸收入血,但吸收程度有明显差异。
To study the kinetics of absorption of aconitine alkaloids in Sini-Tang complex. Using the double-site intubation technique of hepatic portal vein and jugular vein in rats, the blood samples were collected for the determination of aconitine, mesaconitine and hypaconitine by HPLC. The apparent absorption coefficient Absorption kinetics of three aconitum alkaloids in rats. The results showed that the apparent absorption coefficient of mesaconitine, aconitine and hypaconitine in Sini Decoction dry powder were 0.336, 0.090 and 0.166, respectively. The absorbance of mesaconitine in vivo was better than aconitine and times Aconitine The results show that the portal vein and jugular vein cannulation technology is an effective way to study the intestinal absorption of drugs. After oral administration of Sini Decoction to dry powder, all the three kinds of aconitum alkaloids can be absorbed into the blood, but the degree of absorption is obviously different.