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目的分析山东省威海地区老年人高脂血症的治疗干预效果,探讨最佳的干预治疗方式,有效控制老年人高脂血症及其并发症。方法对山东省威海地区某医疗机构临床明确诊断为高脂血症的2 658例年龄在50~80岁的老年患者资料进行回顾性分析。2 658例患者根据是否接受治疗干预分为2组,其中实验组1 798例,对照组860例,实验组按患者血脂各指标升高程度进行饮食调整、改善生活方式以及对上述异常指标有影响的因素加以控制,同时结合非诺贝特药物治疗,对照组无任何干预治疗,定期对其进行血脂的指标检测。观察两组患者血脂各项指标的变化及一般临床症状。结果治疗干预前后,实验组患者的血脂各项检测指标降低趋势明显,特别是甘油三酯(TG)和总胆固醇(TC)水平的初始值与干预期结束时有明显的提高(P<0.01),TG从(2.86±0.36)mmol/L下降到(1.92±0.28)mmol/L,TC从(7.32±0.98)mmol/L下降到(5.6±0.72)mmol/L,而对照组则无明显变化(P>0.05)。结论高脂血症各期的干预治疗无论是饮食治疗、药物治疗还是饮食和药物联合应用,均能从不同程度上改善患者临床症状,降低各项血脂的检测指标,从而降低冠状动脉粥样硬化的风险。
Objective To analyze the therapeutic effects of hyperlipidemia in the elderly in Weihai, Shandong Province, and to explore the best intervention and treatment methods to effectively control hyperlipidemia and its complications in the elderly. Methods A retrospective analysis was made on the data of 2 658 elderly patients aged 50 to 80 years who were clinically diagnosed as hyperlipidemic in a medical institution in Weihai, Shandong Province. 2 658 patients were divided into two groups according to whether they were treated or not, including 1 798 in the experimental group and 860 in the control group. The experimental group was adjusted according to the degree of increase of each index of the patients’ blood lipids to improve the life style and affect the above abnormal indexes Of the factors to be controlled, at the same time with fenofibrate drug treatment, the control group without any intervention, regular detection of lipid indicators. The changes of blood lipid and clinical symptoms in both groups were observed. Results Before and after treatment intervention, the indexes of blood lipids in experimental group decreased significantly, especially the initial values of triglyceride (TG) and total cholesterol (TC) were significantly higher than those at the end of intervention period (P <0.01) , TG decreased from (2.86 ± 0.36) mmol / L to (1.92 ± 0.28) mmol / L and TC decreased from (7.32 ± 0.98) mmol / L to (5.6 ± 0.72) mmol / L, (P> 0.05). Conclusion The interventional treatment of each stage of hyperlipidemia can improve the clinical symptoms and reduce the detection indexes of various blood lipids in different degrees, which can reduce coronary atherosclerosis, no matter dietary therapy, medical treatment or the combination of diet and drugs. risks of.